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KMID : 0882420010610040409
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Korean Journal of Medicine
2001 Volume.61 No. 4 p.409 ~ p.416
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Role of TGF - 1 and TGF - Type 2 receptor in gastric cancer
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Park Dong-Il
Sohn Hee Jung
Song Sang-Yong
Choe Won-Hyeok
Lim Yun-Jeong
Park Sang-Jong
Kim Jae-Jun
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Abstract
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Background: Transforming growth factor-beta (TGF- R) is a potent inhibitor of epithelial cell growth. However, carcinoma cells, unlike normal cells, can escape from negative regulation by TGF-/3 through lack of expression or mutation of TGF- a receptor gene. In this study, we investigated the role of TGF- /31 and TGF- Q type H receptors M811-11) in the progression of gastric cancer.
Methods: We analyzed TGF- /31 and T Q R-H mRNA expression semi-quantitatively, measured by comparative RT-PCR using GAPDH, in 23 patients who underwent gastric resection for gastric cancer. We analyzed the relationship between the clinicopathologic findings and the level of the TGF-,Q 1 and T,811-11 mRNA expression in carcinoma tissues and in adjacent normal tissues of gastric cancer.
Results: (1) TGF-RI and T/3R-H mRNA were expressed in all of the carcinoma tissues and adjacent normal tissues without statistical difference in the level of the expression. (2) The level of TGF- (31 mRNA expression was higher in patients with early gastric cancer, negative lymph nodes or negative perineural invasion. There was no significant correlation between the level of TGF- (31 mR\TA expression and several parameters such as age, gender, tumor size, differentiation, Lauren´s classification, and vascular invasion. (3) There was no significant correlation between the level of T ,811-11 mRNA expression and several prognostic variables described above. (4) There was significant correlation between the level of TGF- /31 and T,8 R-H mRNA in carcinoma tissues.
Conslusion: The above data indicates that TGF- /31 may contribute in the early stages of gastric carcinogenesis. Further studies are required to clarify the role of TGF-,81 in gastric carcinogenesis. (Korean J Med 61:409-416, 2001)
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KEYWORD
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TGF - beta - 1 , Receptor , TGF - β type 2 , Stomach neoplasms
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